T2 \u2014 Tumor is more than 7 centimeters (cm) in greatest dimension, limited to the kidney<\/strong><\/p>\n T2a (left) \u2014 Tumor more than 7 cm but less than or equal to 10 cm (3.9\u201d) in greatest dimension, limited to the kidney T3 \u2014 Tumor extends into major veins or perinephric tissues but not into the ipsilateral adrenal gland and not beyond Gerota\u2019s fascia<\/strong><\/p>\n T3a1 (upper left) \u2014 Tumor invades perirenal and\/or renal sinus fat but not beyond Gerota\u2019s fascia T4 \u2014 Tumor invades beyond Gerota\u2019s fascia or into the adrenal gland<\/strong><\/p>\n T4a (left) \u2014Tumor invades beyond Gerota\u2019s fascia NX \u2014 Regional lymph nodes cannot be assessed M0 \u2014 No distant metastasis Stage I \u2014 T1 | N0 | M0 Source: American Joint Committee on Cancer (AJCC)*<\/em><\/p>\n The grades run from 1 to 4 depending on the appearance of the tumor cells. Normal cells are well formed (differentiated). The less differentiated the cell, the higher the grade. Source: American Joint Committee on Cancer (AJCC)*<\/em><\/p>\n Five-Year Relative Survival Rates (%) by Stage at Diagnosis (2008 – 2014) Source: American Cancer Society Cancer Facts and Figures 2019. Note: Although these are the latest data available, these figures were gathered before targeted therapies came into widespread use. Survival times for metastatic patients are better now.<\/em><\/p>\n View Human Urinary System<\/a> and Kidney Physiology<\/a><\/p>\n \u2022 \u2022 \u2022<\/p>\n *Descriptions used with the permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original source for this material is the AJCC Cancer Staging Handbook, Seventh Edition (2010) published by Springer Science and Business Media LLC, www.springerlink.com.<\/em><\/p>\n Illustrations: Kimberly Battista<\/a><\/span><\/p>\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" According to the TNM* staging system: T = Tumor, N = Node (lymph node), M = Metastasis Tumor (T) Categorizations T1 \u2014 Tumor is 7 centimeters (cm) or less in greatest dimension, limited to the kidney T1a (left) \u2014 Tumor 4 cm (1.6\u201d) or less in greatest dimension, limited to the kidneyT1b (right) \u2014 Tumor more than 4 cm but not more than 7 cm (2.8\u201d), in greatest dimension, limited to the kidney T2 \u2014… More \u2192<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"parent":2659,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-2690","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/pages\/2690","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/comments?post=2690"}],"version-history":[{"count":40,"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/pages\/2690\/revisions"}],"predecessor-version":[{"id":6008,"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/pages\/2690\/revisions\/6008"}],"up":[{"embeddable":true,"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/pages\/2659"}],"wp:attachment":[{"href":"https:\/\/www.ackc.org\/jayedit\/wp-json\/wp\/v2\/media?parent=2690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"http:\/\/www.ackc.org\/wp-content\/uploads\/2015\/02\/T1a-and-1b-600px.png\")
<\/a>T1a (left) \u2014 Tumor 4 cm (1.6\u201d) or less in greatest dimension, limited to the kidney
T1b (right) \u2014 Tumor more than 4 cm but not more than 7 cm (2.8\u201d), in greatest dimension, limited to the kidney<\/p>\n<\/a><\/p>\n
T2b (right) \u2014 Tumor more than 10 cm, limited to the kidney<\/p>\n<\/a><\/p>\n
T3a2 (upper right) \u2014 Tumor grossly extends into the renal vein or its segmental (muscle containing) branches
T3b\u00a0(lower left) \u2014 Tumor grossly extends into the vena cava below the diaphragm
T3c (lower right) \u2014 Tumor grossly extends into the vena cava above the diaphragm or invades the wall of the vena cava<\/p>\n<\/a><\/p>\n
T4b (right) \u2014Tumor extends into the ipsilateral adrenal gland<\/p>\nLymph Node (N) Categorizations<\/h2>\n
N0 \u2014 No regional lymph node metastasis
N1 \u2014 Metastasis in regional lymph node(s)<\/p>\nMetastasis (M) Categorizations<\/h2>\n
M1 \u2014 Distant metastasis<\/p>\nAnatomic Stages<\/h2>\n
Stage II \u2014 T2 | N0 | M0
Stage III \u2014 T1 or T2 | N1 | M0 \u2026or\u2026 T3 | N0 or N1 | M0
Stage IV \u2014 T4 | any N | M0 \u2026or\u2026 any T | any N | M1<\/p>\nHistologic Grade<\/h2>\n
G1 \u2014 Well Differentiated
G2 \u2014 Moderately Differentiated
G3 \u2014 Poorly Differentiated
G4 \u2014 Undifferentiated<\/p>\nSurvival Rates<\/h2>\n
All Stages:\u00a0 \u00a075%
Local:\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a093%
Regional:\u00a0 \u00a0 \u00a069%
Distant:\u00a0 \u00a0 \u00a0 \u00a0 12%<\/p>\n